B2M Monoclonal Antibody for Human(Homo sapiens) | EIAab.comB2M Monoclonal Antibody for Human(Homo sapiens)

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Index > Protein center > B2M(Gene name) > Human

B2M (Gene name),

Beta-2-microglobulin (Protein name ), B2MG_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

B2M(CDABP0092;HDCMA22P);

Protein name:

Beta-2-microglobulin;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.

Function:

Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.

Subcellular Location:

Secreted Detected in serum and urine.

Protein Attributes:

Sequence length:

119

Sequence:

50:

100:

119:

RVNHVTLSQP | KIVKWDRDM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07654

KEGG:

hsa:567

String:

P61769

STRING:

9606.ENSP00000340858

UniGene:

Hs.534255

MIM:

109700

SMR:

P61769

Uniprot:

P61769

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ELISA Kit for Human Beta-2-microglobulin

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E0260m

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96T

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ELISA Kit for Human Beta-2-microglobulin

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E0260h

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96T

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ELISA Kit for Human Beta-2-microglobulin

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E0260r

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96T

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ELISA Kit for Human Beta-2-microglobulin

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ELISA Kit for Human Beta-2-microglobulin

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E0260b

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96T

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ELISA Kit for Human Beta-2-microglobulin

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E0260c

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96T

ELISA Kit for Human Beta-2-microglobulin

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E0260d

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ELISA Kit for Human Beta-2-microglobulin

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E0260p

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96T

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CLIA Kit for Human Beta-2-microglobulin

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U0260r

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96T

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CLIA Kit for Human Beta-2-microglobulin

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U0260d

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96T

CLIA Kit for Human Beta-2-microglobulin

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CLIA Kit for Human Beta-2-microglobulin

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U0260c

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96T

CLIA Kit for Human Beta-2-microglobulin

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U0260h

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96T

CLIA Kit for Human Beta-2-microglobulin

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U0260b

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96T

CLIA Kit for Human Beta-2-microglobulin

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U0260p

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96T

CLIA Kit for Human Beta-2-microglobulin

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U0260m

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96T

Polyclonal Antibody for Human Beta-2-microglobulin

Cat.:

P0260Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Beta-2-microglobulin

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P0260Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Beta-2-microglobulin

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P0260Rb-m

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40ug/0.2ml

Monoclonal Antibody for Human Beta-2-microglobulin

Cat.:

M0260h

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Packing:

40ug

Protein for Human Beta-2-microglobulin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"The human beta 2-microglobulin gene. Primary structure and definition of the transcriptional unit."
Guessow D. , Rein R. , Ginjaar I. , Hochstenbach F. , Seemann G. , Kottman A. , Ploegh H.L.
J. Immunol.139:3132-3138(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
2.

"Cloning of human beta-microglobulin gene and its high expression in Escherichia coli."
He X.H. , Xu L.H. , Liu Y. , Zeng Y.Y.
Sheng Wu Gong Cheng Xue Bao20:99-103(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Peripheral blood.
3.

"Human mRNA for beta 2-microglobulin."
Matsumoto K. , Minamitani T.
Submitted (1998-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Cervix carcinoma.
4.

"Genetic variation in immune response genes."
Tan J. , Ong R. , Hibberd M.L. , Seielstad M.
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
5.

"A novel gene from human dendritic cell."
Zhao Z. , Huang X. , Li N. , Zhu X. , Cao X.
Submitted (1998-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Dendritic cell.
6.

"Pediatric leukemia cDNA sequencing project."
Zhou J. , Yu W. , Tang H. , Mei G. , Tsang Y.T.M. , Bouck J. , Gibbs R.A. , Margolin J.F.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Leukemia.
7.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
8.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Trachea.
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Retina.
tissue: Skin.
11.

"The beta-2-microglobulin mRNA in human Daudi cells has a mutated initiation codon but is still inducible by interferon."
Rosa F. , Berissi H. , Weissenbach J. , Maroteaux L. , Fellous M. , Revel M.
EMBO J.2:239-243(1983) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-21
12.

"Use of synthetic oligonucleotides as hybridization probes: isolation of cloned cDNA sequences for human beta 2-microglobulin."
Suggs S.V. , Wallace R.B. , Hirose T. , Kawashima E.H. , Itakura K.
Proc. Natl. Acad. Sci. U.S.A.78:6613-6617(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 10-119
13.

"The complete amino acid sequence of beta 2-microglobulin."
Cunningham B.A. , Wang J.L. , Berggard I. , Peterson P.A.
Biochemistry12:4811-4822(1973) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-119
14.

"Polymerization of intact beta 2-microglobulin in tissue causes amyloidosis in patients on chronic hemodialysis."
Gorevic P.D. , Munoz P.C. , Casey T.T. , DiRaimondo C.R. , Stone W.J. , Prelli F.C. , Rodrigues M.M. , Poulik M.D. , Frangione B.
Proc. Natl. Acad. Sci. U.S.A.83:7908-7912(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-119;SUBUNIT;INVOLVEMENT IN AMYLOIDOSIS
15.

"Isolation of a granulocyte inhibitory protein from uraemic patients with homology of beta 2-microglobulin."
Haag-Weber M. , Mai B. , Hoerl W.H.
Nephrol. Dial. Transplant.9:382-388(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-41
tissue: Plasma.
16.

"Biochemical characterization of serum and urinary beta 2 microglobulin in end-stage renal disease patients."
Argiles A. , Derancourt J. , Jauregui-Adell J. , Mion C. , Demaille J.G.
Nephrol. Dial. Transplant.7:1106-1110(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 21-40;SUBCELLULAR LOCATION
17.

"Amino acid sequence of a modified beta 2-microglobulin in renal failure patient urine and long-term dialysis patient blood."
Momoi T. , Suzuki M. , Titani K. , Hisanaga S. , Ogawa H. , Saito A.
Clin. Chim. Acta236:135-144(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 22-119;SUBCELLULAR LOCATION;PYROGLUTAMATE FORMATION AT GLN-22 (FORM PI 5.3)
tissue: Urine.
18.

"Glycation of human beta 2-microglobulin in patients with hemodialysis-associated amyloidosis: identification of the glycated sites."
Miyata T. , Inagi R. , Wada Y. , Ueda Y. , Iida Y. , Takahashi M. , Taniguchi N. , Maeda K.
Biochemistry33:12215-12221(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN AMYLOIDOSIS;GLYCATION AT ILE-21; LYS-39; LYS-61; LYS-68; LYS-78; LYS-111 AND LYS-114;IDENTIFICATION BY MASS SPECTROMETRY
19.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
20.

"Structure of the human class I histocompatibility antigen, HLA-A2."
Bjorkman P.J. , Saper M.A. , Samraoui B. , Bennett W.S. , Strominger J.L. , Wiley D.C.
Nature329:506-512(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.5 ANGSTROMS)
21.

"Refined structure of the human histocompatibility antigen HLA-A2 at 2.6-A resolution."
Saper M.A. , Bjorkman P.J. , Wiley D.C.
J. Mol. Biol.219:277-319(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS)
22.

"1H NMR assignments and secondary structure of human beta 2-microglobulin in solution."
Okon M. , Bray P. , Vucelic D.
Biochemistry31:8906-8915(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
23.

"The three-dimensional structure of a class I major histocompatibility complex molecule missing the alpha 3 domain of the heavy chain."
Collins E.J. , Garboczi D.N. , Karpusas M.N. , Wiley D.C.
Proc. Natl. Acad. Sci. U.S.A.92:1218-1221(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
24.

"Bound water structure and polymorphic amino acids act together to allow the binding of different peptides to MHC class I HLA-B53."
Smith K.J. , Reid S.W. , Harlos K. , McMichael A.J. , Stuart D.I. , Bell J.I. , Jones E.Y.
Immunity4:215-228(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
25.

"Crystal structure of monomeric human beta-2-microglobulin reveals clues to its amyloidogenic properties."
Trinh C.H. , Smith D.P. , Kalverda A.P. , Phillips S.E. , Radford S.E.
Proc. Natl. Acad. Sci. U.S.A.99:9771-9776(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119;DISULFIDE BOND
26.

"A structural basis for immunodominant human T cell receptor recognition."
Stewart-Jones G.B.E. , McMichael A.J. , Bell J.I. , Stuart D.I. , Jones E.Y.
Nat. Immunol.4:657-663(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 21-119 OF HLA-A/B2M HETERODIMER IN COMPLEX WITH TRAC AND TRBC1;DISULFIDE BOND
27.

"Conformation of amyloid fibrils of beta2-microglobulin probed by tryptophan mutagenesis."
Kihara M. , Chatani E. , Iwata K. , Yamamoto K. , Matsuura T. , Nakagawa A. , Naiki H. , Goto Y.
J. Biol. Chem.281:31061-31069(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 21-119;AMYLOID FORMATION;DISULFIDE BOND
28.

"A native to amyloidogenic transition regulated by a backbone trigger."
Eakin C.M. , Berman A.J. , Miranker A.D.
Nat. Struct. Mol. Biol.13:202-208(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 21-119;DISULFIDE BOND
29.

"High-resolution crystal structure of beta2-microglobulin formed at pH 7.0."
Iwata K. , Matsuura T. , Sakurai K. , Nakagawa A. , Goto Y.
J. Biochem.142:413-419(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.13 ANGSTROMS) OF 21-119;DISULFIDE BOND
30.

"DE loop mutations affect beta2-microglobulin stability and amyloid aggregation."
Ricagno S. , Colombo M. , de Rosa M. , Sangiovanni E. , Giorgetti S. , Raimondi S. , Bellotti V. , Bolognesi M.
Biochem. Biophys. Res. Commun.377:146-150(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119;MUTAGENESIS OF ASP-79;DISULFIDE BOND
31.

"The controlling roles of Trp60 and Trp95 in beta2-microglobulin function, folding and amyloid aggregation properties."
Esposito G. , Ricagno S. , Corazza A. , Rennella E. , Guemral D. , Mimmi M.C. , Betto E. , Pucillo C.E. , Fogolari F. , Viglino P. , Raimondi S. , Giorgetti S. , Bolognesi B. , Merlini G. , Stoppini M. , Bolognesi M. , Bellotti V.
J. Mol. Biol.378:887-897(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119;MUTAGENESIS OF TRP-80;DISULFIDE BOND
32.

"Human beta-2 microglobulin W60V mutant structure: Implications for stability and amyloid aggregation."
Ricagno S. , Raimondi S. , Giorgetti S. , Bellotti V. , Bolognesi M.
Biochem. Biophys. Res. Commun.380:543-547(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 21-119;MUTAGENESIS OF TRP-80;DISULFIDE BOND
33.

"Familial hypercatabolic hypoproteinemia caused by deficiency of the neonatal Fc receptor, FcRn, due to a mutant beta2-microglobulin gene."
Wani M.A. , Haynes L.D. , Kim J. , Bronson C.L. , Chaudhury C. , Mohanty S. , Waldmann T.A. , Robinson J.M. , Anderson C.L.
Proc. Natl. Acad. Sci. U.S.A.103:5084-5089(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT HYCATHYP PRO-11;CHARACTERIZATION OF VARIANT HYCATHYP PRO-11

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